![]() Pelargonidin-3-O-galactoside (Fr.) Peonidin-3-O-glucoside (Fr.) Cyanidin-3-O-galactoside (Ideain) (Fr.) Pelargonidin-3-O-rutinoside (Fr.) Cyanidin-3-O-rutinoside (Antirrhinin) (Fr.) Cyanidin-3-O-robinobioside (Fr.) Delphinidin-3-O-galactoside (Fr.) Pelargonidin-3-O-robinobioside (Fr.) Pelargonidin-3-O-glucoside (Callistephin) (Fr.) Cyanidin-3-O-glucoside (Chrysanthemin) (Fr.) Carbohydrates Fructose (Fr.) Glucose (Fr.) Sucrose (Fr.) Carotenoids (13Z, 13'Z)-Lutein (Fr.) ( Kaempferol-3-O-galactoside (fr.) Quercetin-3-O-glucuronide (Miquelianin) (Fr., L.) Quercetin-3-O-rutinoside (Rutin) (Fl., Fr., L.) Iridoids Loganin (Fl.) Sweoside (Fr.) Secologanin (L.) Cornuside (Fr.) Loganic acid (Fl., Fr.) Monoterpenes 1,8-Cineol (Fl.) Borneol (Fl.) Camphor (Fl.) Carvacrol (Fl.) Carvon (Fl.) Verbenone (Fl.) α-Terpineol (Fl.) β-Thujene (Fl.) Limonene (Fl.) Organic acids Fumaric acid (Fr., L.) Isocitric acid (Fr.). In conclusion, we have shown loganic acid to be the main iridoid constituent in the European cultivar of the cornelian cherry, and proven that the cornelian cherry could have protective effects on diet-induced hypertriglicerydemia and atherosclerosis through enhanced PPAR alpha protein expression and via regulating oxidative stress and inflammation. Moreover, the cornelian cherry had a significant protective effect on diet-induced oxidative stress in the liver, as well as restored upregulated proinflammatory cytokines serum levels. ![]() Simvastatin treatment did not affect PPAR-alpha expression. ![]() Cornelian cherry significantly increased PPAR alpha protein expression in the liver, indicating that its hypolipidemic effect may stem from enhanced fatty acid catabolism. The administering of the cornelian cherry led to a 44% significant decrease in serum triglyceride levels, as well as prevented development of atheromatous changes in the thoracic aorta. Two iridoids - loganic acid and cornuside - and five anthocyanins were identified as the main constituents of the cornelian cherry. Cornelian cherry (100 mg/kg b.w.) or simvastatin (5 mg/kg b.w.) were administered orally for 60 days. In a subsequent in vivo study the protective effect of the cornelian cherry on diet-induced hyperlipidemia was studied using a rabbit model fed 1% cholesterol. The HPLC-MS method was used for determining active constituents in cornelian cherry. mas L.) fruits lyophilisate on lipid levels, PPAR alpha protein expression, atheromatous changes in the aorta, oxido-redox state, and proinflammatory cytokines in hypercholesterolemic rabbits. This study was conducted to evaluate the constituents and impact of cornelian cherry (C. mas and its protection against ovarian-cessation obesity, oxidative stress and adipokines imbalance that belong to important risk factors of cardiovascular diseases.Cornelian cherry (Cornus mas L.) fruits have been used in traditional cuisine and in folk medicine in various countries. To our best knowledge this is the first study that demonstrated bone-protective properties of C. It ameliorated ovariectomy-induced decrease in femoral and tibial bone mineral density (BMD), prevented the deterioration in Young’s modulus and flexural strength and counteracted ovariectomy-induced decrease in serum calcium level. CM reduced oxidative stress normalizing GPx, and SOD activity, and GSH/GSSG ratio. It counteracted adipokines imbalance, increasing visfatin and resistin and decreasing adiponectin levels. Intragastrical administration of CM ameliorated ovariectomy-induced weight gain and decreased accumulation of visceral fat tissue. CM) extract on ovariectomy-induced metabolic changes including bone loss, obesity development, adipokines imbalance and oxidative stress. The aim of the current study was to to investigate the influence of cornelian cherry ( Cornus mas L.
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